Department of Pharmaceutical Sciences, College of Pharmacy
We have discovered that the hop natural product, xanthohumol, exerts anti-obesity and anti-hyperglycemic effects in animal models of metabolic syndrome. Current research on xanthohumol, now marketed as a dietary supplement and food additive, is focused on its fate in the human body and its effects on gene regulation relevant to lipid and glucose metabolism. The Stevens lab also investigates the beneficial effects of vitamin C in the prevention of tolerance against nitrate therapy.
Research in the Stevens laboratory is aimed at determining the role and function of vitamins and dietary phytochemicals in human health and disease. Mass spectrometry-based metabolomics is a new direction in the laboratory for discovery of biological effects and mechanisms of actions.